SUBSTITUTED PTERIDINONES, PYRIMIDINES, PYRROLOPYRIMIDINES, AND PURINES AS P90 RIBOSOMAL S6 PROTEIN KINASE-2 (RSK2) INHIBITORS: PHARMACOPHORE MODELING DATA

The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt maybelline green concealer multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained fo

Fisheries observer programs represent the most reliable way to collect data on fisheries bycatch.However, their limited coverage leads to important data gaps that preclude bycatch mitigation at the basin scale.Habitat models developed from available fisheries observer programs offer a potential solution to fill these gaps.We focus on tropical tuna

This issue of our Journal has some special features and innovations.First of all, it is a more capacious issue than usual: it contains two special issues, which we decided to put side by side to ensure that both would be published in an issue in the year 2022.The first is dedicated to the topic of the call that we presented two issues roman atwood

Abstract Many pollinators, including bumble bees, are in decline.Such declines are known to be driven by a number of interacting factors.Decreases in bee populations may also negatively impact john tory hair the key ecosystem service, pollination, that they provide.Pesticides and parasites are often cited as two of the drivers of bee declines, part